Cyclo-oxygenase II inhibitors in the treatment of neoplastic fever
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Updated: Sep 21, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice
Published on: August 25, 2012
Satheesh K Kathula1, Ketan Shah, Hari Polenakovik
1Department of Medicine, Wright State University, Dayton, Ohio, USA. satish@kathula.com
Abstract:
Neoplastic fever is relatively common in cancer patients. Naproxen is one of the most commonly used non-steroidal anti-inflammatory drugs for the treatment of neoplastic fever. Naproxen is associated with platelet dysfunction and gastrointestinal side effects. We substituted rofecoxib, a cyclooxygenase-II inhibitor, for naproxen in patients with a previous history of, or a newly diagnosed, neoplastic fever in whom naproxen was relatively contraindicated. In all patients the fever resolved completely without any side effects.
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