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[Gene mapping of a nonsyndromic hearing impairmint family]
Lin Cheng1, Yaoqin Gong, Qiji Liu
1Department of Medical Genetics, Medical School of Shandong University, Jinan, Shandong, 250012 P. R. China. gongyaoqin@yahoo.com
Objective:
To map the gene responsible for nonsyndromic hearing impairment in a consanguineous family.
Methods:
Firstly, X chromosome scanning was used to exclude X chromosome. Secondly, candidate gene analyzing and genome scanning were performed by homozygosity mapping. Then, additional markers flanking the tightly linked marker were tested to confirm linkage and decide the candidate region.
Results:
The nonsyndromic hearing impairment of this family was autosomal recessive. Twenty-five known genes were excluded. Autosomal genome scanning indicated that D17S1293 was tightly linked with disease gene. And further study mapped the disease gene to a 5.07 cM interval bounded by D17S1850 and D17S1818.
Conclusion:
The disease gene of the family is mapped to a 5.07 cM interval between D17S1850 and D17S1818, which is a new locus of autosomal recessive nonsyndromic hearing impairment.