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[Association study of heroin dependence and catechol-O-methyltransferase gene]

Liping Cao¹, Tao Li, Xiehe Liu

¹Institute of Mental Health, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P.R. China. caoliping@hotmail.com

Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics

|April 4, 2003

Abstract

Objective:

To detect the relationship between heroin dependence and catechol-O-methyltransferase (COMT) gene.

Methods:

Genotype and allele frequencies of 108 val/met and 900 Ins C/Del C polymorphisms of COMT gene were examined in 313 heroin-dependent subjects and 214 normal controls.

Results:

No differences in genotype and allele frequencies of 108 val/met polymorphism of COMT gene were observed between heroin-dependent subjects and normal controls (genotype-wise: chi-square=1.67, P=0.43; allele-wise: chi-square=1.23, P=0.27). No differences in genotype and allele frequencies of 900 Ins C/Del C polymorphism of COMT gene were observed between heroin-dependent subjects and normal controls (genotype-wise: chi-square=3.73, P=0.16; allele-wise: chi-square=0.76, P=0.38).

Conclusion:

The results suggested that neither 108 val/met polymorphism nor 900 Ins C/Del C polymorphism of COMT gene was associated with heroin dependence.

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