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Updated: Sep 26, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
[Studies on the relationship between vitamin D receptor gene polymorphism and osteoporosis in postmenopausal women]
Jun Chen1, Liping Zhang, Junfeng Qiu
1Department of Endocrinology, the Second Teaching Hospital of Chongqing Medical University, Chongqing, 400010 P. R. China. Chen_96938@163.com
Objective:
To determine the relationship between vitamin D receptor (VDR) gene polymorphism and osteoporosis in postmenopausal women.
Methods:
The polymerase chain reaction-restriction fragment length polymorphism was used to detect VDR genotype in 40 patients with osteoporosis and 21 healthy postmenopausal women.
Results:
In the patients with osteoporosis, the bb, Bb, and BB genotype accounted for 82.5%, 17.5% and 0, respectively; in healthy groups, they were 85.71%, 14.29% and 0, respectively (P>0.05).
Conclusion:
Significant association between VDR genotype and osteoporosis in Chinese women was observed in this study.
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