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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Targeted therapy and pharmacogenomic programs

Syma Iqbal1, Heinz Josef Lenz

  • 1Division of Oncology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.

Cancer
|April 4, 2003
PubMed

Insights

Predicting chemotherapy response and toxicity is crucial. Tumor profiling, including genetic markers, shows promise for personalizing treatments with fluoropyrimidines and platinums, guiding future clinical trials.

Area of Science:

  • Oncology
  • Pharmacogenomics

Background:

  • Chemotherapy aims to predict patient response and treatment toxicity.
  • Tumor profiling technologies measure protein expression, gene expression, and genetic polymorphisms.
  • These markers can predict patient response to specific chemotherapeutics.

Purpose of the Study:

  • To explore the potential of tumor profiling in predicting chemotherapy outcomes.
  • To identify specific chemotherapeutics, like fluoropyrimidines and platinums, where marker-based prediction is feasible.

Main Methods:

  • Utilizing advanced technology for comprehensive tumor profiling.
  • Measuring protein expression, gene expression levels, and genetic polymorphisms.
  • Correlating molecular profiles with patient response and toxicity data.

Main Results:

  • Established markers can predict treatment outcomes for fluoropyrimidines and platinums.
  • Tumor profiling demonstrates potential for personalized chemotherapy selection.

Conclusions:

  • Prospective clinical trials are necessary to validate the benefits of tumor profiling.
  • Personalized profiling is expected to improve chemotherapy response rates and reduce toxicity.

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