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Related Experiment Videos

Bone mineral decrease in the leg with unilateral chronic occlusive arterial disease.

M Laroche1, L Moulinier, P Leger

  • 1Service de Rhumatologie, CHU Rangueil, 1 Avenue J. Poulhès, 31403 Toulouse, France. laroche.m@chu-toulouse.fr

Clinical and Experimental Rheumatology
|April 4, 2003
PubMed
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Arterial disease in the lower limbs leads to reduced bone mineral density in the affected leg, suggesting ischemia negatively impacts bone health. This study highlights a link between arteriosclerosis and osteoporosis.

Area of Science:

  • Orthopedics and Vascular Medicine
  • Bone Metabolism and Ischemia

Background:

  • Epidemiological studies suggest a link between osteoporosis and arteriosclerosis.
  • The potential role of ischemia in arteriosclerosis-induced bone loss requires investigation.

Purpose of the Study:

  • To compare bone mineral density (BMD) in both legs of patients with unilateral arterial disease of the lower limbs.
  • To investigate if arteriosclerosis induces bone mineral loss via ischemia.

Main Methods:

  • Dual X-ray absorptiometry (DXA) was used to measure bone mineral content (BMC) and BMD in 25 patients with unilateral lower limb arterial disease.
  • Measurements were taken of the femoral neck, femur, tibia, foot, and ankle in both affected and unaffected legs.

Main Results:

Related Experiment Videos

  • Significantly lower BMD was observed in the femur (-3.7%) and foot/ankle (-3%) of the affected leg.
  • Bone mineral content was also lower (-5.3%) in the affected leg, while fat and muscle mass remained similar.
  • Tibial BMD was identical between legs; non-significant decreases were noted in the femoral neck and trochanter.

Conclusions:

  • Ischemia resulting from lower limb arterial disease appears to directly impair bone mineralization.
  • This finding supports a pathological link between arteriosclerosis and reduced bone density.