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Voxeldoes: a computer program for 3-D dose calculation in therapeutic nuclear medicine
Isabelle Gardin1, Lionel G Bouchet, Karine Assié
1CHB, CHU, Laboratoire Universitaire QUANT.I.F., Rouen, France. isabelle.gardin@rouen.fnclcc.fr
Cancer Biotherapy & Radiopharmaceuticals
|April 4, 2003
Summary
VoxelDose software calculates patient-specific 3-D radiation dose maps using SPECT imaging. Validation showed good agreement for most organs, though tumor and liver doses require further investigation.
Area of Science:
- Medical Physics
- Nuclear Medicine
- Radiotherapy Dosimetry
Background:
- Accurate patient-specific dosimetry is crucial for effective radionuclide therapy.
- Existing methods for calculating 3-D dose distributions from SPECT data have limitations.
Purpose of the Study:
- To develop and validate VoxelDose, a software tool for voxel-level 3-D dose map calculation.
- To assess the accuracy of VoxelDose by comparing calculated doses with phantom measurements.
Main Methods:
- SPECT data reconstruction with attenuation and scatter correction.
- Generation of 3-D cumulated activity maps by integrating SPECT data.
- Computation of 3-D dose maps using Fourier Transform convolution with MIRD S values.
Main Results:
- VoxelDose software was developed for patient-specific 3-D dose calculations.
- Validation using an abdominal phantom with 111In showed good agreement for spleen, kidneys, and other organs.
- Significant differences were observed for tumor and liver dose calculations, attributed to TLD positioning and quantification limits.
Conclusions:
- VoxelDose is a promising tool for patient-specific dosimetry, particularly for organs with good agreement.
- Further research is needed to address discrepancies in tumor and liver dosimetry, focusing on scatter correction and partial volume effects.