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Related Experiment Videos

Epidermal activity in annular dermatophytosis.

S H Berk, N S Penneys, G D Weinstein

    Archives of Dermatology
    |April 1, 1976
    PubMed
    Summary

    The outer edge of ringworm lesions shows significantly higher skin cell turnover than normal skin. This increased epidermal turnover at the rim may explain how these fungal infections grow and spread.

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    Area of Science:

    • Dermatology
    • Mycology
    • Cell Biology

    Background:

    • Annular tinea corporis presents as ring-shaped skin lesions caused by dermatophyte fungi.
    • The growth and spread (morphogenesis) of these lesions are not fully understood.
    • Epidermal cell turnover is a key factor in skin health and disease.

    Purpose of the Study:

    • To investigate epidermal cell proliferation in active lesions of annular tinea corporis.
    • To compare cell turnover rates at the lesion rim versus the center and normal skin.
    • To explore the role of epidermal turnover in the pathophysiology of tinea corporis.

    Main Methods:

    • Assessed tritiated thymidine labeling index in five patients with annular tinea corporis.
    • Measured labeling indexes in the lesion rim, center, and intermediate areas.
    • Compared lesion indexes with those of normal skin samples.
    • Performed histologic examination of lesion and normal skin.

    Main Results:

    • Significantly higher thymidine labeling indexes were observed at the lesion rim compared to normal skin (mean, 4.2 times).
    • Labeling indexes in the lesion center and intermediate areas were not significantly different from normal skin.
    • Histologic examination revealed epidermal thickening across all areas of the tinea corporis lesions.

    Conclusions:

    • Increased epidermal turnover at the rim of annular tinea corporis lesions is a key finding.
    • This elevated cell proliferation at the border may be crucial for lesion expansion and development.
    • Findings suggest a dynamic process at the lesion edge contributing to dermatophytosis pathophysiology.

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