Related Experiment Video
Updated: Aug 17, 2026

Production of Chemicals by Klebsiella pneumoniae Using Bamboo Hydrolysate as Feedstock
Published on: June 29, 2017
[Progress in biotechnological production of pyruvic acid]
Li-Ming Liu1, Yin Li, Guo-Cheng Du
1Key Lab of Industrial Biotechnology, Ministry of Education, Environmental Biotechnology Laboratory, School of Biotechnology, Southern Yangtze University, Wuxi 214036, China.
Abstract:
Pyruvate, an important organic acid, is widely used in the industries of pharmaceuticals, chemicals, agrochemicals, food additives and so on. Compared with the chemical method, biotechnological production of pyruvic acid is an alternative approach because of the low cost and high product quality. In this article, biosynthesis of pyruvate, including direct fermentative production and resting cell method as well as enzymatic method, was discussed. Furthermore, a comparison of these different methods was proposed. Since, a multi-vitamin auxotrophic strain of Torulopsis glabrata is the most competitive strain for industrial production of pyruvate, emphasis was therefore placed on the development of strains screening and fermentation optimization. Finally, some suggestions were put forward to improve the research in this field in the near future.
Related Concept Videos
Fates of Pyruvate
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
Bioreactor Controls-III
Upstream Processing
Production of Alcohol
Production of Organic Acids
Production of Pharmaceuticals

