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The tetranucleotide repeat polymorphism C2_4_4: population data and linkage disequilibria with HLA class I
Simone Stadlbacher1, Eva-Maria Dauber, Sabine Wenda
1University of Vienna, Division of Blood Group Serology, Waehringer Guertel 18-20, A-1090 Wien, Austria.
Immunobiology
|April 5, 2003
Abstract:
The tetranucleotide repeat locus C2_4_4 situated in the HLA class I region (6p21.3) and the HLA-ABC specificities were investigated in an Austrian population sample of 240 unrelated Caucasoid individuals. The analysis of the linkage disequilibrium between C2_4_4 and HLA class I showed several significant values, especially when factors coded for by so-called "superhaplotypes" were considered; such linkage disequilibria are of importance for the practical use of HLA coded short tandem repeats.