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Human chromosome 17 in essential hypertension.

J Knight1, P B Munroe, J C Pembroke

  • 1Clinical Pharmacology, The William Harvey Research Institute Bart's and The London Queen Mary, University of London Charterhouse Square, UK. J.Knight@iop.kcl.ac.uk

Annals of Human Genetics
|April 5, 2003
PubMed
Summary

Researchers reviewed evidence suggesting a gene on chromosome 17 causes essential hypertension. Despite studies in rodents and humans, no specific gene has been identified yet, but research is ongoing.

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Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Nephrology

Background:

  • Hypertension impacts 30% of Western adults, a key risk factor for kidney disease, stroke, and heart disease.
  • The complex etiology of hypertension involves genetic and environmental factors, with precise causes still under investigation.
  • Genetic research methods, successful for Mendelian traits, are now applied to complex diseases like hypertension.

Purpose of the Study:

  • To review evidence implicating chromosome 17 genes in human essential hypertension.
  • To summarize findings from rodent models and human studies, including pseudohypoaldosteronism type II.
  • To outline various genetic approaches used in hypertension research.

Main Methods:

  • Review of rodent models for hypertension.

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  • Analysis of human hypertension studies, including monogenic traits like pseudohypoaldosteronism type II.
  • Examination of candidate gene studies, genome screens, and linkage analyses.

    • Main Results:

    • Evidence suggests the involvement of one or more genes on chromosome 17 in human essential hypertension.
    • Studies in rodents and humans, including specific genetic disorders, have been conducted.
    • No definitive gene on human chromosome 17 has been identified to date that causes essential hypertension.

    Conclusions:

    • While chromosome 17 is implicated, no specific gene has been confirmed to cause human essential hypertension.
    • Ongoing fine-mapping and candidate gene studies in both rodents and humans are crucial.
    • Further research is anticipated to identify genetic factors contributing to hypertension.