Related Experiment Video
Updated: Jul 31, 2026
Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
Published on: November 18, 2022
Failure of immunotherapy to prevent, arrest or reverse diabetic lumbosacral plexopathy
D W Zochodne1, D Isaac, C Jones
1Department of Clinical Neurosciences, Room 182A, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta, Canada, T2N 4N1. dzochodn@ucalgary.ca
Three patients are described who had severe and progressive diabetic lumbosacral plexopathy despite active immunosuppressive therapy. One patient developed the condition while immunosuppressed for a cardiac transplant and two others progressed while receiving intravenous gamma globulin. The cases raise questions about current unsupported practices of treatment for this condition. Robust clinical trial evidence is required before immunosuppression can be recommended.
Three patients are described who had severe and progressive diabetic lumbosacral plexopathy despite active immunosuppressive therapy. One patient developed the condition while immunosuppressed for a cardiac transplant and two others progressed while receiving intravenous gamma globulin. The cases raise questions about current unsupported practices of treatment for this condition. Robust clinical trial evidence is required before immunosuppression can be recommended.
