Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet physiology: in cold blood.

Robert K Andrews1, Michael C Berndt

  • 1Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3168, Victoria, Australia.

Current Biology : CB
|April 5, 2003
PubMed
Summary

Refrigerated platelets are quickly removed after transfusion. This occurs because liver Kupffer cells use Mac-1 integrin to identify and engulf aggregated platelet GPIb receptors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Platelet triggering receptor expressed on myeloid cells-like transcript 1 regulation in healthy donors and patients at risk of bleeding and thrombosis.

Journal of thrombosis and haemostasis : JTH·2026
Same author

Platelet dysfunction in immune thrombocytopenia: Finding clinical subsets with platelet phenotypes.

British journal of haematology·2025
Same author

A glycoprotein VI signaling defect in newly formed platelets generated in stress thrombopoiesis.

Journal of thrombosis and haemostasis : JTH·2025
Same author

Patients with Waldenström macroglobulinemia have impaired platelet and coagulation function.

Blood advances·2024
Same author

Notch1 regulates hepatic thrombopoietin production.

Blood·2024
Same author

Tissue inhibitors of metalloproteinases (TIMPs) modulate platelet ADAM10 activity.

Platelets·2023

Area of Science:

  • Immunology
  • Hematology
  • Cell Biology

Background:

  • Long-term storage of platelets for transfusion is limited.
  • Refrigerated platelets exhibit rapid clearance from circulation post-transfusion, hindering their therapeutic use.

Purpose of the Study:

  • To investigate the mechanism behind the rapid clearance of refrigerated platelets from circulation.
  • To identify the cellular interactions involved in platelet removal after transfusion.

Main Methods:

  • The study focused on the interaction between Kupffer cells in the liver and transfused platelets.
  • Investigated the role of specific cell surface receptors, including Mac-1 integrin and GPIb receptor, in mediating platelet clearance.

Main Results:

  • Evidence suggests that Mac-1 integrin on Kupffer cells recognizes clustered GPIb receptors on platelets.
  • This recognition triggers the phagocytosis of platelets by Kupffer cells in the liver.

Conclusions:

  • The interaction between Kupffer cell Mac-1 and platelet GPIb is a key mechanism for rapid platelet clearance.
  • Understanding this process may lead to strategies for improving platelet storage and transfusion efficacy.

Related Experiment Videos