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Skeletal muscle RAS and exercise performance.

Alun Jones1, David R Woods

  • 1Department of Cardiovascular Genetics, 3rd Floor, Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK.

The International Journal of Biochemistry & Cell Biology
|April 5, 2003
PubMed
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A local muscle renin-angiotensin system (RAS) influences exercise performance. Targeting angiotensin-converting enzyme (ACE) activity may improve strength and endurance, particularly in certain populations.

Area of Science:

  • Physiology
  • Molecular Biology
  • Exercise Science

Background:

  • Evidence suggests a local renin-angiotensin system (RAS) exists in tissues, indicated by gene expression and physiological responses.
  • This review focuses on the components of a functional paracrine muscle RAS.

Purpose of the Study:

  • To review evidence for a functional muscle RAS.
  • To explore the impact of local muscle RAS on human exercise performance through pharmacological and genetic studies.

Main Methods:

  • Review of existing literature on muscle RAS components and function.
  • Analysis of studies involving pharmacological interventions targeting RAS components (e.g., ACE inhibitors).
  • Examination of genetic studies investigating the relationship between RAS gene variants and exercise performance.

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Main Results:

  • A local muscle RAS likely involves both in situ synthesis and uptake of RAS components from circulation.
  • Reduced angiotensin-converting enzyme (ACE) activity can improve physical performance in heart failure patients and slow muscle strength decline in elderly women.
  • Genetic variations in ACE and bradykinin (BK) metabolism are linked to strength and endurance performance, respectively, potentially through muscle hypertrophy, substrate availability, and fiber type modulation.

Conclusions:

  • The muscle RAS plays a significant role in regulating skeletal muscle function and exercise capacity.
  • Modulating ACE activity presents a potential therapeutic strategy for enhancing physical performance and counteracting age- or disease-related decline.
  • Genetic factors influencing the muscle RAS contribute to individual differences in strength and endurance capabilities.