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Experimental arthrogryposis caused by viral myopathy
Archives of Neurology
|May 1, 1976
Summary
Viral myopathy can cause arthrogryposis multiplex congenita (AMC) joint deformities. This study demonstrates that paralysis from a viral infection in chick embryos leads to joint ankylosis, suggesting a viral cause for some human AMC cases.
Area of Science:
- Developmental biology
- Virology
- Orthopedics
Background:
- Immobilization is a suspected cause of arthrogryposis multiplex congenita (AMC).
- Previous studies induced AMC-like changes via motor neuron damage or neuromuscular blockade.
Purpose of the Study:
- To investigate the effects of viral myopathy-induced paralysis on joint development.
- To determine if primary muscle disease can cause arthrogrypotic deformities.
Main Methods:
- Intravenous injection of Coxsackievirus A2 into chick embryos on day 7.
- Monitoring for myositis, paralysis, and viral presence using electron microscopy and immunofluorescence.
- Assessing joint development and ankylosis post-infection.
Main Results:
- Within 48 hours, infected embryos developed severe myositis and paralysis.
- Viral particles were confirmed in muscle cells.
- Muscle tissue significantly degraded within 3-4 days.
- Joint ankylosis, consistent with human AMC, was observed.
Conclusions:
- Primary myopathy leading to paralysis can induce arthrogrypotic joint deformities.
- A viral etiology should be considered for certain human cases of AMC.