Heat shock response by the hyperthermophilic archaeon Pyrococcus furiosus
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Updated: Sep 26, 2026

Adaptation at the Extremes of Life: Experimental Evolution with the Extremophile Archaeon Sulfolobus acidocaldarius
Published on: June 14, 2024
Keith R Shockley1, Donald E Ward, Swapnil R Chhabra
1Department of Chemical Engineering, North Carolina State University, Raleigh 27695-7905, USA.
Abstract:
Collective transcriptional analysis of heat shock response in the hyperthermophilic archaeon Pyrococcus furiosus was examined by using a targeted cDNA microarray in conjunction with Northern analyses. Differential gene expression suggests that P. furiosus relies on a cooperative strategy of rescue (thermosome [Hsp60], small heat shock protein [Hsp20], and two VAT-related chaperones), proteolysis (proteasome), and stabilization (compatible solute formation) to cope with polypeptide processing during thermal stress.
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