Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neural stem cells: an overview.

Rossella Galli1, Angela Gritti, Luca Bonfanti

  • 1Stem Cell Research Institute, DIBIT, Hospital San Raffaele, Via Olgettina 58, Milan, Italy.

Circulation Research
|April 5, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generation and characterization of the hiPSC line CSSi023-A (16154) from a patient with ADOA caused by an OPA1 variant.

Stem cell research·2026
Same author

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma-1 Receptor Modulation.

The FEBS journal·2026
Same author

A conserved bioelectrical signature defines subventricular zone-derived human fetal neural stem cells and tracks their differentiation state.

Frontiers in cell and developmental biology·2026
Same author

Mixed Signals and Interspecies Variation in the Plasticity of Adult Mammal Brains.

Cells·2026
Same author

Single-cell transcriptomic profiling of human fetal neural stem cells isolated from the subventricular zone.

Frontiers in cell and developmental biology·2026
Same author

A blueprint for local and distal invasion programs in glioblastoma.

Nature communications·2026

Adult mammalian central nervous system (CNS) contains neural stem cells (NSCs) in specific brain regions like the subventricular zone (SVZ). These NSCs generate new neurons throughout life and exhibit remarkable plasticity, differentiating into various cell types.

Area of Science:

  • Neuroscience
  • Stem Cell Biology

Background:

  • The mature mammalian central nervous system (CNS) was once thought to be static, but recent findings reveal ongoing cell turnover.
  • This turnover is supported by the persistence of neural stem cells (NSCs) in specific brain regions.

Purpose of the Study:

  • To review the nature and functional properties of adult mammalian CNS stem cells.
  • To discuss the neurogenic potential and plasticity of these neural stem cells.

Main Methods:

  • Literature review focusing on adult mammalian CNS stem cells.
  • Analysis of studies on cell turnover, precursor cells, and neural stem cells (NSCs).

Main Results:

  • The subventricular zone (SVZ) of the forebrain is identified as a primary neurogenic area and a rich source of NSCs.

Related Experiment Videos

  • NSCs from the SVZ contribute neurons to the olfactory bulb throughout life and can be expanded in culture.
  • These NSCs demonstrate significant plasticity, differentiating into cell types beyond neural lineages, a phenomenon discussed critically.

    • Conclusions:

    • Adult mammalian brains harbor functional neural stem cells (NSCs) capable of lifelong neurogenesis.
    • The plasticity of these neuroectodermal stem cells extends beyond the CNS, with potential to differentiate into diverse cell types.
    • Further research is needed to understand the implications and mechanisms of this broad differentiation capacity.