PPARs: Versatile Targets for Future Therapy for Obesity, Diabetes and Cardiovascular Diseases

Peroxisome proliferator activated receptors (PPARs) are fertile targets for drug discovery. They are targets for two widely used classes of drugs, the fibrates and thiazolidinediones. Remarkable advances have been made in our understanding of the mechanism of action of these receptors over the last 10 years. Further research and development of the three identified PPARs, PPARalpha, PPARbeta and PPARgamma, may help develop more efficacious drugs in the treatment of dyslipidemia, cardiovascular diseases, obesity and diabetes. (c) 2002 Prous Science. All rights reserved.