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Updated: Aug 11, 2026

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy
Published on: May 22, 2020
[Uveal lymphoid infiltration with systemic extension]
J J Barbón García1, C Viña Escalar, C L Menéndez Fernández
1Servicio de Oftalmología, Hospital San Agustín, Avilés, Asturias. jjbarbon@telecable.es
Case Report:
We report the case of a patient who was surgically treated in his right eye because of an uncontrollable glaucoma and a retinal detachment without retinal break. Ultrasound and computed tomography showed diffuse choroidal thickening. During 6 years of follow-up, he developed a major ocular and orbitary invasion and bone marrow infiltration. He was treated by enucleation and chemotherapy with apparent total remission.
Discussion:
Reactive lymphoid hyperplasia of the uvea consists of a lymphocytic proliferation that primarily involves the uveal tract. This process is regarded as a low malignant condition, but this case of late diagnosis showed a tendency to orbital and systemic extension.
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