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[Life-threatening theophylline intoxication: a variant of Munchhausen syndrome by proxy]
1Abteilung für allgemeine Kinderheilkunde, Klinik und Poliklinik für Kinderheilkunde, Universitätsklinikum Münster. dfoell@uni-muenster.de
Insights
A 6-month-old infant experienced prolonged seizures due to theophylline poisoning, a case of non-accidental poisoning by the mother. This highlights a rare presentation of Munchausen syndrome by proxy.
Area of Science:
- Pediatrics
- Toxicology
- Child Abuse
Background:
- Theophylline is a common medication for respiratory conditions.
- Theophylline toxicity can manifest with various symptoms, including seizures.
Observation:
- A 6-month-old infant presented with persistent seizures, hypokalemia, diarrhea, and tachycardia.
- Symptoms persisted despite medical interventions and improved electroencephalogram (EEG) readings.
Findings:
- The infant's condition was ultimately diagnosed as theophylline poisoning.
- The mother was identified as the source of the non-accidental poisoning.
Implications:
- This case represents a rare instance of non-accidental theophylline poisoning within the context of Munchausen syndrome by proxy.
- It underscores the importance of considering non-accidental poisoning in unexplained pediatric illnesses, even in the absence of prior reports.
Abstract:
We report of a prematurely born infant, who was admitted to hospital at the age of 6 months due to seizures. The seizures continued despite of an improved electroencephalogram due to varying medications. The boy had episodes of hypokaliaemia, diarrhea, and tachycardia which were treated in critical care unit. Not before 3 months of continued treatment and diagnostic work up in three different hospitals had passed the underlying poisoning with theophylline by the mother was proved. The toxicity of theophylline is well known. Adverse reactions occur frequently during theophylline therapy. There are numerous reports of suicidal intoxications with theophylline. Non-accidental poisoning with theophylline has not yet been reported in the context of Munchausen syndrome by proxy.
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