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Updated: Sep 26, 2026

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets
Published on: March 12, 2019
[NO-inhibiting activity of radioprotectors]
S Ia Proskuriakov1, N G Kucherenko, M N Semenenko
1Medical Radiology Research Centre, Russian Academy of Medical Sciences, Obninsk, 249036 Russia. noo@mrrc.obninsk.ru
Abstract:
The effect of radioprotectors of different structure on the syntheses of nitric oxide induced by endotoxin in mice was studied. Using ESR-spectroscopy and spin trap techniques, it was shown that compounds of different chemical structure, such as aminothiols, isothiuronium derivatives, thiazolines, indolylalkylamines and others, suppressed the nitric oxide production in a whole body. The analysis of the relevant literature has confirmed the phenomenon described by the authors: radioprotectors show NO-inhibiting activity.
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