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Non-typhi salmonella in children with severe malaria

J O Oundo1, F Muli, S Kariuki

  • 1Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.

East African Medical Journal
|April 8, 2003
PubMed

Insights

Non-typhi Salmonella (NTS) and severe malaria frequently co-occur in children, posing a significant health challenge. Many NTS isolates exhibit multidrug resistance, complicating treatment options for these coinfections.

Area of Science:

  • Pediatric Infectious Diseases
  • Tropical Medicine
  • Microbiology

Background:

  • Plasmodium falciparum malaria is a major cause of childhood illness in endemic regions.
  • Non-typhi Salmonella (NTS) infections are also significant pediatric pathogens.
  • The co-occurrence of malaria and NTS may influence disease severity and outcomes.

Purpose of the Study:

  • To investigate the association between Plasmodium falciparum malaria and non-typhi Salmonella infections in hospitalized children.
  • To determine the prevalence of NTS in children with malaria and assess antibiotic resistance patterns.

Main Methods:

  • A cross-sectional hospital-based study was conducted at Kilifi District Hospital.
  • Blood and stool cultures were analyzed from 9,147 children admitted with malaria between 1997 and 2001.
  • Antibiotic sensitivity testing was performed on isolated NTS strains.

Main Results:

  • Non-typhi Salmonella was identified in 1.10% of malaria admissions.
  • NTS was found in 18.6% of positive blood cultures and 28.4% of stool cultures.
  • Multidrug resistance (MDR) was observed in 33.6% of NTS isolates, with significant resistance to common antibiotics.

Conclusions:

  • The co-existence of NTS and severe malaria is a notable public health issue in the study area.
  • A substantial proportion of NTS isolates demonstrate multidrug resistance, necessitating careful antibiotic selection.
  • Further case-controlled studies are recommended to understand the interplay between NTS and malaria parasite infections.
Abstract

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