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Non-typhi salmonella in children with severe malaria
1Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
East African Medical Journal
|April 8, 2003
Summary
Non-typhi Salmonella (NTS) and severe malaria frequently co-occur in children, posing a significant health challenge. Many NTS isolates exhibit multidrug resistance, complicating treatment options for these coinfections.
Area of Science:
- Pediatric Infectious Diseases
- Tropical Medicine
- Microbiology
Background:
- Plasmodium falciparum malaria is a major cause of childhood illness in endemic regions.
- Non-typhi Salmonella (NTS) infections are also significant pediatric pathogens.
- The co-occurrence of malaria and NTS may influence disease severity and outcomes.
Purpose of the Study:
- To investigate the association between Plasmodium falciparum malaria and non-typhi Salmonella infections in hospitalized children.
- To determine the prevalence of NTS in children with malaria and assess antibiotic resistance patterns.
Main Methods:
- A cross-sectional hospital-based study was conducted at Kilifi District Hospital.
- Blood and stool cultures were analyzed from 9,147 children admitted with malaria between 1997 and 2001.
- Antibiotic sensitivity testing was performed on isolated NTS strains.
Main Results:
- Non-typhi Salmonella was identified in 1.10% of malaria admissions.
- NTS was found in 18.6% of positive blood cultures and 28.4% of stool cultures.
- Multidrug resistance (MDR) was observed in 33.6% of NTS isolates, with significant resistance to common antibiotics.
Conclusions:
- The co-existence of NTS and severe malaria is a notable public health issue in the study area.
- A substantial proportion of NTS isolates demonstrate multidrug resistance, necessitating careful antibiotic selection.
- Further case-controlled studies are recommended to understand the interplay between NTS and malaria parasite infections.