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Chemical genomics-based target identification and validation of anti-angiogenic agents
1Chemical Genomics Laboratory, Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, Seoul 143-747, Korea. kwonhj@sejong.ac.kr
Abstract:
The recent use of chemical genomics to identify bioactive small molecules that interact with specific proteins has had a tremendous impact on both the functional analysis of genes and drug development. Accordingly, the current review focuses on the utilization of this new research engine in the target identification and validation of anti-angiogenic agents capable of regulating the growth and spread of cancer cells. In addition, the use of chemical genomics to discover novel anti-angiogenic agent targets and to validate their biological relevancy is providing new insights into the biological role of targets in angiogenesis as well as advancing the development of new anti-angiogenic agents.