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Biological activity of some monocyclic- and bicyclic beta-lactams with specified functional groups
Jih Ru Hwu1, Krishna S Ethiraj, Gholam H Hakimelahi
1Organosilicon and Synthesis Laboratory, Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan 11529, Republic of China. jrhwu@mx.nthu.edu.tw
Abstract:
This Review contains our recent studies on evaluation of biological activities associated with monocyclic beta-lactams and bicyclic beta-lactam antibiotics containing various heteroatoms. A series of bicyclic beta-lactams was synthesized, which possessed electron-withdrawing groups, such as an ester, mesylate, and triflate functionality. These beta-lactams exhibited enhanced antibacterial activity.
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