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Related Experiment Videos

Infections and urinary stone disease.

Nadeem U Rahman1, Maxwell V Meng, Marshall L Stoller

  • 1Department of Urology, School of Medicine, University of California-San Francisco, San Francisco, CA 94143-0738, USA.

Current Pharmaceutical Design
|April 8, 2003
PubMed
Summary

Urinary tract infections are linked to stone formation. New treatments target urease-producing bacteria and explore novel approaches for calcium-based stones and catheter-associated infections.

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Area of Science:

  • Urology
  • Microbiology
  • Biomedical Engineering

Background:

  • The link between urinary infections and stone formation is ancient.
  • Bacterial degradation of urea is a known cause of struvite stones.
  • Urinary tract catheterization is associated with significant infection and morbidity.

Purpose of the Study:

  • To review current and future therapeutic strategies for urinary stone disease.
  • To explore novel approaches for preventing and treating catheter-associated infections and biofilms.
  • To discuss the role of microorganisms in stone formation and prevention.

Main Methods:

  • Literature review of studies on urinary stone pathogenesis and treatment.
  • Analysis of research on urease-inhibiting therapies and novel urease-inhibitors.

Related Experiment Videos

  • Examination of advancements in catheter coatings to prevent bacterial colonization and biofilm formation.

    • Main Results:

    • Urease-inhibitors and antibiotics are effective for urease-producing bacterial stones.
    • Potential roles for nanobacteria and Oxalobacter formingenes in calcium-based stones are identified.
    • Antimicrobial catheter coatings (ciprofloxacin, hydrogel, silver) show promise in reducing infections and encrustation.

    Conclusions:

    • Targeted therapies exist for specific bacterial stone types.
    • Further research into urease-inhibitors and glycosaminoglycan enhancement is warranted.
    • Novel strategies for catheter-associated infections may significantly improve patient outcomes.