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Organ printing: computer-aided jet-based 3D tissue engineering.

Vladimir Mironov1, Thomas Boland, Thomas Trusk

  • 1Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425, USA. mironovv@musc.edu

Trends in Biotechnology
|April 8, 2003
PubMed
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Organ printing, a computer-aided 3D tissue-engineering method, offers a solution to the organ shortage crisis. This technology enables rapid prototyping and accelerated assembly of vascularized living human organs.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Developmental Biology

Background:

  • The organ transplantation crisis necessitates innovative solutions.
  • Vascularized 3D soft organ assembly remains a significant challenge in tissue engineering.

Purpose of the Study:

  • To introduce organ printing as a computer-aided, jet-based 3D tissue-engineering approach for creating living human organs.
  • To present a novel rapid prototyping technology for accelerated tissue and organ assembly.

Main Methods:

  • Organ printing involves three sequential steps: pre-processing (blueprint development), processing (actual printing), and postprocessing (maturation).
  • A specialized cell printer capable of printing gels, single cells, and cell aggregates was developed.
  • Thermo-reversible gel layers are used as a substrate for sequential layer-by-layer printing and solidification.

Related Experiment Videos

  • An engineering approach combined with developmental biology concepts (embryonic tissue fluidity) was employed.

    • Main Results:

    • A novel rapid prototyping 3D organ printing technology has been created.
    • This technology significantly accelerates and optimizes the assembly of engineered tissues and organs.

    Conclusions:

    • Organ printing presents a viable solution to the organ transplantation crisis.
    • The developed technology holds the potential to revolutionize the field of tissue engineering and organ fabrication.