Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myocardial protection during aortic valve replacement.

D G Mulder, G N Olinger, D H McConnell

    The Annals of Thoracic Surgery
    |February 11, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Superior neurologic recovery after 15 minutes of normothermic cardiac arrest using an extracorporeal life support system for optimized blood pressure and flow.

    Perfusion·2013
    Same author

    Ventricular structures must be understood during surgical restoration for heart failure.

    Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society·2007
    Same author

    Continuous antegrade blood cardioplegia: cold vs. tepid.

    The Thoracic and cardiovascular surgeon·2002
    Same author

    The structure and function of the healthy helical and failing spherical heart. Overview: the ventricular band and its surgical implications.

    Seminars in thoracic and cardiovascular surgery·2002
    Same author

    The structure and function of the helical heart and its buttress wrapping. I. The normal macroscopic structure of the heart.

    Seminars in thoracic and cardiovascular surgery·2002
    Same author

    The structure and function of the helical heart and its buttress wrapping. II. Interface between unfolded myocardial band and evolution of primitive heart.

    Seminars in thoracic and cardiovascular surgery·2002

    Maintaining a beating heart during aortic valve replacement (AVR) with continuous coronary perfusion significantly improves post-operative cardiac performance compared to hypothermic arrest, reducing the need for inotropic support.

    Area of Science:

    • Cardiovascular Surgery
    • Cardiac Anesthesia
    • Myocardial Protection

    Background:

    • Aortic valve replacement (AVR) is a critical procedure for managing aortic valve disease.
    • Effective myocardial protection strategies are essential to minimize cardiac damage during AVR.
    • Current techniques include hypothermic arrest and continuous coronary perfusion.

    Purpose of the Study:

    • To compare the efficacy of two myocardial protection strategies during AVR.
    • To evaluate the impact of sustained electrical fibrillation versus a beating heart on post-perfusion cardiac performance.

    Main Methods:

    • A prospective study comparing two groups of 40 patients undergoing AVR.
    • Group A: Myocardial protection via topical hypothermic arrest or continuous coronary perfusion with sustained electrical fibrillation.

    Related Experiment Videos

  • Group B: Continuous coronary perfusion with the heart maintained in a beating state.

    • Main Results:

    • Operative mortality was similar between groups (10% in Group A vs. 5% in Group B).
    • Post-perfusion cardiac performance differed significantly: 43% of Group A patients required inotropic support versus only 3% in Group B.
    • One patient in Group B experienced persistent ventricular fibrillation despite reversion attempts.

    Conclusions:

    • Continuous coronary perfusion with a beating heart is superior for myocardial preservation during AVR.
    • This strategy leads to better post-operative cardiac function and reduced need for inotropic support.
    • Maintaining the heart in a beating state optimizes myocardial protection in AVR patients.