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Comparison of gallbladder function obtained with regular CCK-8 and pharmacy-compounded CCK-8
Shakuntala Krishnamurthy1, Jeri Cerulli-Switzer, Nicholas Chapman
1Nuclear Medicine Department, Tuality Community Hospital/Tuality Healthcare, 335 SE 8th Avenue, Hillsboro, OR 97123, USA. gtkrishna@aol.com
Summary
Pharmacy-compounded cholecystokinin octapeptide-8 (CCK-8) yields results similar to regular CCK-8 for gallbladder function. A 30-minute interval ensures consistent gallbladder ejection fraction measurements.
Area of Science:
- Gastroenterology
- Nuclear Medicine
- Pharmacology
Background:
- Cholecystokinin octapeptide-8 (CCK-8) is crucial for assessing gallbladder function.
- Evaluating pharmacy-compounded CCK-8 against regular CCK-8 is essential for clinical application.
Purpose of the Study:
- To compare the efficacy of pharmacy-compounded CCK-8 with regular CCK-8 in evaluating gallbladder function.
- To determine if pharmacy-compounded CCK-8 provides comparable results to regular CCK-8.
Main Methods:
- Quantitative cholescintigraphy was performed on 20 patients with suspected gallbladder disease.
- Patients received sequential 10-minute infusions of regular CCK-8 and pharmacy-compounded CCK-8, separated by a 30-minute interval.
- Gallbladder ejection fraction, latent period, ejection period, and ejection rate were measured for both agents.
Main Results:
- Both CCK-8 formulations produced similar, closely correlated results for all measured gallbladder functions.
- No potentiation or inhibition was observed between sequential doses of CCK-8.
- Pharmacy-compounded CCK-8 demonstrated high similarity to regular CCK-8.
Conclusions:
- Pharmacy-compounded CCK-8 is a viable alternative to regular CCK-8 for gallbladder function assessment.
- A minimum 30-minute interval between doses is recommended for accurate and reproducible results.
- The study supports the use of pharmacy-compounded CCK-8 in clinical settings.