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Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study.

Dario Maggio1, Mauro Barabani, Marco Pierandrei

  • 1Gerontology and Geriatrics, University of Perugia, 06122 Perugia, Italy. dario_maggio@msn.com

The Journal of Clinical Endocrinology and Metabolism
|April 8, 2003
PubMed
Summary

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Elderly women with osteoporosis have lower levels of key antioxidants, suggesting reduced antioxidant defenses may play a role in this bone disease. Further research is needed to confirm this link.

Area of Science:

  • Biochemistry
  • Gerontology
  • Nutritional Science

Background:

  • Epidemiological studies suggest a link between vitamin C intake and bone mineral density.
  • Limited data exists on plasma antioxidant levels in individuals with osteoporosis.

Purpose of the Study:

  • To investigate if antioxidant defenses are diminished in elderly osteoporotic women.
  • To determine if osteoporosis is associated with increased oxidative stress.

Main Methods:

  • Measured plasma levels of vitamins C, E, and A, and uric acid in 75 osteoporotic women and 75 controls.
  • Assessed enzymatic activities of superoxide dismutase and glutathione peroxidase.
  • Quantified plasma malondialdehyde as a marker of lipid peroxidation.

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Main Results:

  • Osteoporotic subjects exhibited consistently lower levels of dietary and endogenous antioxidants compared to controls.
  • Plasma malondialdehyde levels did not significantly differ between osteoporotic and control groups.
  • Antioxidant defenses were markedly decreased in osteoporotic women.

Conclusions:

  • Elderly osteoporotic women show significantly reduced antioxidant defenses.
  • The study highlights a potential role for diminished antioxidant capacity in osteoporosis pathogenesis.
  • Further investigation is required to elucidate the mechanisms and implications of antioxidant depletion in osteoporosis.