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Release kinetics of 5-fluorouracil-loaded microspheres on an experimental rat glioma
Valérie-Gaelle Roullin1, Laurent Lemaire, Marie-Claire Venier-Julienne
1INSERM ERIT-M 0104, 10 rue A. Boquel, F-49100 Angers, France.
Background:
Biodegradable loaded systems are promising devices for controlled and sustained release of anticancer drugs to brain tumours. We investigated the influence of drug-release profiles of 5-fluorouracil-loaded microspheres designed for the treatment of malignant gliomas.
Materials And Methods:
2.5 mg 5-FU delivered by either fast. (1 formulation) or slow-(2 formulations) 5-FU release microspheres (MS) were tested in C6-glioma rat brains. Tumor response was assessed by T2-weighted MRI.
Results:
All treated animals, whatever the release profile considered, displayed a comparable 50% increase in life span versus controls. Delays in C6-glioma development appeared to correspond to the in vitro release periods of MS. In terms of curative prospect, complete remission was only observed in 11% of 5-FU-treated animals (4 out of 38).
Conclusion:
Formulation was unambiguously implicated in the response observed after local delivery of 5-FU to glioma.