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The effect of commonly used drugs on angiogenesis
Maryam R Sartippour1, Ernesto De Leon, Rosalio Rubio
1University of California, Los Angeles, Department of Surgery, Division of Oncology, Los Angeles, CA 90095, USA.
Background:
Within the last decade, there has been much interest in the area of tumor angiogenesis, with the advent of many new anti-angiogenic drugs undergoing testing in cancer clinical Phases II and III. Many of the cancer patients also take multiple medications for a variety of chronic illnesses. Because of possible drug-drug interactions, it is important to investigate the effect that commonly prescribed medications may have on angiogenesis.
Materials And Methods:
In this pilot study, we assessed the effect of the following drugs on in vitro angiogenesis: atenolol, diltiazem, enalapril, disopyramide, mexiletine, coumadin, cimetidine and omeprazole.
Results & Conclusion:
We observed that, although some of these drugs at massive doses inhibited endothelial proliferation, they did not affect in vitro angiogenesis at human therapeutic ranges.
Insights
Commonly prescribed medications do not impact tumor angiogenesis in vitro at therapeutic doses. This study investigated potential drug interactions with anti-angiogenic cancer therapies, finding no significant effects in human therapeutic ranges.
Area of Science:
- Oncology
- Pharmacology
- Vascular Biology
Background:
- Significant interest in tumor angiogenesis and anti-angiogenic cancer drugs.
- Cancer patients often use multiple medications for chronic conditions.
- Potential for drug-drug interactions impacting cancer treatment efficacy.
Purpose of the Study:
- To assess the in vitro effect of commonly prescribed drugs on angiogenesis.
- To identify potential interactions between these drugs and anti-angiogenic therapies.
Main Methods:
- Pilot study evaluating atenolol, diltiazem, enalapril, disopyramide, mexiletine, coumadin, cimetidine, and omeprazole.
- Assessed impact on in vitro angiogenesis.
- Examined effects at human therapeutic ranges and massive doses.
Main Results:
- Some tested drugs inhibited endothelial proliferation at massive doses.
- No significant inhibition of in vitro angiogenesis was observed at human therapeutic ranges.
Conclusions:
- Commonly prescribed medications do not appear to interfere with angiogenesis at therapeutic levels.
- Further investigation into drug interactions with anti-angiogenic cancer drugs is warranted.