Down-regulated expression of the CCAAT/enhancer binding protein alpha and beta genes in human hepatocellular
Minoru Tomizawa1, Kazuo Watanabe, Hiromitsu Saisho
1Division of Pathology, Chiba Cancer Center Research Institute, Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan. nihminor-cib@umin.ac.jp
Abstract:
CCAAT/enhancer binding protein alpha (C/EBP alpha) and C/EBP beta, liver specific transcription factors, are involved in hepatocyte proliferation and differentiation. The expression level of the C/EBP alpha and C/EBP beta genes were examined between tumor and non-tumorous tissues of the same hepatocellular carcinoma patients with quantitative real-time polymerase chain reactions. The expression of both the C/EBP alpha and C/EBP beta genes was down-regulated in the majority of the tumor specimens compared with corresponding non-tumorous tissues. Patients whose expression of either C/EBP alpha or C/EBP beta was higher in tumors than non-tumorous tissues survived longer than those whose expression was lower in tumors. Higher expression of C/EBP alpha or C/EBP beta in tumors was reversibly correlated with the tumor size and progression of the clinical stage. These data imply that the comparison of C/EBP alpha and C/EBP beta expression between tumors and non-tumorous regions could be a prognostic marker for patients with hepatocellular carcinoma.
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