Related Experiment Video
Updated: Aug 5, 2026
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
The pathology of lymphangioma circumscriptum
The British Journal of Dermatology
|May 1, 1976
Summary
Lymphangioma circumscriptum involves deep lymphatic cisterns and superficial vesicles. Excising the cisterns may improve treatment and cosmetic outcomes for this lymphatic malformation.
Area of Science:
- Dermatology
- Vascular Malformations
- Lymphatic System Research
Background:
- Lymphangioma circumscriptum is a complex lymphatic malformation.
- Its pathogenesis and optimal treatment remain areas of investigation.
Purpose of the Study:
- To elucidate the nature and pathogenesis of lymphangioma circumscriptum.
- To identify improved therapeutic strategies for better clinical and cosmetic results.
Main Methods:
- Long-term clinical observation and study of lymphangioma circumscriptum cases.
- Postulation of lesion structure based on anatomical and physiological understanding.
- Cannulation studies to assess lymphatic cistern pressure dynamics.
Main Results:
- The lesion is characterized by deep, pulsating lymphatic cisterns communicating with superficial vesicles via dermal lymphatics.
- These cisterns appear to be a sequestered part of the lymphatic system, not directly connected to the general lymphatic network.
- Pulsation of cisterns generates pressure, leading to secondary dilatation of superficial lymphatics (vesicles).
Conclusions:
- Lymphangioma circumscriptum is hypothesized to arise from deep, pulsating lymphatic cisterns.
- Surgical excision of these subcutaneous cisterns, preserving overlying skin, is proposed as a potentially effective treatment.
- This approach may lead to improved therapeutic success and cosmetic outcomes.
Related Concept Videos
01:16Lymphatic Vessels and Lymph Transport
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
01:15Development of the Lymphatic System
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...