Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet purinergic receptors.

Satya P Kunapuli1, Robert T Dorsam, Soochong Kim

  • 1Temple University Medical School, 3420 North Broad Street, Philadelphia, PA 19140, USA. kunapuli@nimbus.temple.edu

Current Opinion in Pharmacology
|April 12, 2003
PubMed
Summary

Platelet activation relies on P2Y(1) and P2Y(12) receptors, stimulated by ADP released during agonist exposure. P2X(1) receptors also influence platelet shape and calcium signaling, with P2Y(12) receptor cloning aiding downstream event studies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel noncanonical Src-mammalian STE20-like kinase 1 (MST1)-Akt/glycogen synthase kinase-3β (GSK3β) pathway drives platelet activation and thrombosis.

Journal of thrombosis and haemostasis : JTH·2026
Same author

Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids.

NAM journal·2026
Same author

Adjusting the Preincubation Conditions to Enhance the Ames Test for Detecting the Mutagenicity of N-Nitrosamines.

Environmental and molecular mutagenesis·2026
Same author

Additive effects of ceftiofur-neomycin combination against multidrug-resistant pathogenic <i>Escherichia coli</i> in a murine infection model.

Veterinarni medicina·2026
Same author

Standardization of canine platelet-rich plasma preparation and its functional characterization.

Journal of veterinary science·2026
Same author

Case Report: Dose-dependent response to oclacitinib in a dog with Sézary syndrome.

Frontiers in veterinary science·2025

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Hematology

Background:

  • Platelet activation is crucial for hemostasis and thrombosis.
  • Adenosine diphosphate (ADP) is a key mediator released by activated platelets.
  • Purinergic receptors, including P2Y and P2X families, play significant roles in platelet function.

Purpose of the Study:

  • To elucidate the role of P2Y(1) and P2Y(12) receptors in ADP-mediated platelet activation.
  • To investigate the contribution of P2X(1) receptors to platelet shape change and calcium signaling.
  • To highlight the significance of P2Y(12) receptor cloning and genetic manipulation for future research.

Main Methods:

  • Review of existing literature on purinergic receptor signaling in platelets.
  • Discussion of agonist-induced ADP secretion (thrombin, thromboxane, collagen).

Related Experiment Videos

  • Mention of P2Y(12) receptor cloning and knockout mouse models.

    • Main Results:

    • P2Y(1) and P2Y(12) receptors are central to ADP-driven platelet activation.
    • P2X(1) receptors contribute to platelet shape modulation and enhanced calcium responses.
    • Genetic studies of P2Y(12) offer insights into its signaling pathways.

    Conclusions:

    • P2Y(1) and P2Y(12) receptors are critical targets for understanding platelet activation mechanisms.
    • P2X(1) receptors modulate key platelet responses.
    • The P2Y(12) receptor is a valuable subject for further molecular and physiological investigation.