Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conservation of Declining Populations02:07

Conservation of Declining Populations

Conservation of declining population focuses on ways of detecting, diagnosing, and halting a population decline. The approach uses methods to prevent populations from going extinct.
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Kaplan-Meier Approach01:24

Kaplan-Meier Approach

The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adherence to the Mediterranean diet and risk of pancreatic cancer: an analysis of 2.3 million participants in the Pooling Project of Prospective Studies of Diet and Cancer (DCPP).

European journal of epidemiology·2026
Same author

CBCRisk-Mastectomy: A Prediction Tool to Aid Contralateral Prophylactic Mastectomy Decision- making.

The Journal of surgical research·2026
Same author

CBCRisk-Mastectomy: A Risk Prediction Tool to Aid Contralateral Prophylactic Mastectomy Decision Making.

medRxiv : the preprint server for health sciences·2026
Same author

Highlights of the San Antonio breast cancer symposium 2025 (Part 2).

Future oncology (London, England)·2026
Same author

Highlights of the San Antonio Breast Cancer Symposium 2025 (Part 1).

Future oncology (London, England)·2026
Same author

Trends in breast cancer death rates from ductal carcinoma in situ versus invasive cancer in the United States.

Breast cancer research : BCR·2025

Related Experiment Video

Updated: Jul 9, 2026

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

Why is breast-cancer mortality declining?

Ismail Jatoi1, Anthony B Miller

  • 1Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Ismail.Jatoi@hbg.amedd.army.mil

The Lancet. Oncology
|April 12, 2003
PubMed
Summary

Breast cancer mortality declined in the 1990s, but mammography screening effects have a 10-year delay. Improved treatments and earlier detection of palpable tumors, not just screening, likely caused the rapid decline in breast cancer deaths.

Area of Science:

  • Oncology
  • Public Health
  • Epidemiology

Background:

  • Age-adjusted breast cancer mortality rates were stable or increasing for decades before the 1990s in developed nations.
  • A decline in breast cancer mortality began in the early 1990s, coinciding with the widespread implementation of mammography screening programs.
  • Randomized trials suggest a 10-year lag between the introduction of mammography screening and its observable impact on mortality statistics.

Purpose of the Study:

  • To critically evaluate the attributed causes of the observed decline in breast cancer mortality rates.
  • To investigate the potential impact of adjuvant systemic therapy and earlier tumor detection on breast cancer mortality trends.
  • To assess the evolving relationship between advances in breast cancer treatment and the value of mammography screening.

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
03:07

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

Published on: August 19, 2025

Related Experiment Videos

Last Updated: Jul 9, 2026

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
03:07

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

Published on: August 19, 2025

Main Methods:

  • Review of population statistics on age-adjusted breast cancer mortality trends.
  • Analysis of the temporal relationship between mammography screening program implementation and mortality declines.
  • Synthesis of evidence regarding the impact of adjuvant systemic therapy and early detection on breast cancer outcomes.

Main Results:

  • The observed decline in breast cancer mortality in the early 1990s occurred too rapidly to be solely attributed to mammography screening.
  • While a reduction in breast cancer risk may have contributed, adjuvant systemic therapy and earlier detection of palpable tumors are likely primary drivers of the mortality reduction.
  • Advances in breast cancer treatment may be surpassing the current demonstrated value of mammography screening in reducing mortality.

Conclusions:

  • The rapid decrease in breast cancer mortality is likely multifactorial, with significant contributions from improved treatments and earlier detection.
  • Rethinking the primary drivers of breast cancer mortality decline is crucial for future public health strategies.
  • Continued monitoring of mortality trends is essential for evaluating the effectiveness of novel diagnostic and therapeutic approaches in breast cancer care.