Plasminogen activators in the endometrium of women using intrauterine contraceptive devices

Plasminogen activators in the endometrium before and after the insertion of an intrauterine contraceptive device (IUCD) were studied; an increase in the concentration was found following IUCD insertion in 16 of the 20 women. This change will enhance endometrial fibrinolysis and may explain the increased menstrual bleeding which usually follows insertion of an IUCD.