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Related Experiment Videos

Not all effector CD8+ T cells are alike.

Donald R Drake1, Thomas J Braciale

  • 1The Beirne B. Carter Center for Immunology Research, University of Virginia, Box 801386, MR4 Bldg., HSC Box 4012, Charlottesville, VA 22906, USA.

Microbes and Infection
|April 12, 2003
PubMed
Summary

Naive CD8+ T cells become activated cytotoxic T lymphocytes (CTLs) when they encounter specific peptide-MHC complexes on antigen-presenting cells (APCs). The quality of this initial immune stimulation determines the long-term functional state of these crucial immune cells.

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Area of Science:

  • Immunology
  • Cellular Biology
  • T cell activation

Background:

  • Naive CD8+ T cells patrol the body, interacting with antigen-presenting cells (APCs) in lymphoid tissues.
  • This interaction involves sampling peptide-MHC class I complexes on APC surfaces.
  • Successful T cell receptor (TCR)-peptide-MHC binding initiates T cell activation.

Purpose of the Study:

  • To investigate the regulatory mechanisms governing naive CD8+ T cell activation.
  • To understand how the quality of initial T cell stimulation impacts effector function.
  • To explore the long-term functional states of CD8+ T cells and their progeny.

Main Methods:

  • Circulation of naive CD8+ T cells in bloodstream and lymphoid tissues.
  • Interaction with professional antigen-presenting cells (APCs).

Related Experiment Videos

  • Generation of activated cytotoxic T lymphocytes (CTLs).

    • Main Results:

    • T cell activation is tightly regulated to prevent immunopathology.
    • The quality of stimulation influences the functional competency of antigen-specific CTLs.
    • CD8+ T cells and their effector progeny can maintain diverse long-term activation states.

    Conclusions:

    • Proper T cell activation is critical for effective immunity against infected and transformed cells.
    • The induction and maintenance phases of an immune response shape CTL function.
    • Immune memory is characterized by diverse and long-lasting effector cell states.