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Updated: Sep 26, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
Published on: April 16, 2012
Regulation of the generation and maintenance of T-cell memory: a direct, default pathway from effectors to memory
1Trudeau Institute, PO Box 59, 100 Algonquin Avenue, Saranac Lake, NY 12983, USA. sswain@northnet.org
Abstract:
Memory T cells are derived directly from effector cells without need for additional antigen, TcR triggering or induced cytokines. A large fraction of effectors can become memory cells without division, supporting a default pathway with little further differentiation. This suggests that the same signals during infection/vaccination determine the extent and nature of both effector and memory cell development.
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