Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proteases and lung injury.

Theo J Moraes1, Chung-Wai Chow, Gregory P Downey

  • 1Division of Respiratory Medicine, Department of Paediatrics, Hospital for Sick Children, and Institute of Medical Sciences, Faculty of Medicine, the University of Toronto, Ontario, Canada.

Critical Care Medicine
|April 12, 2003
PubMed
Summary

Neutrophil elastase plays a key role in acute respiratory distress syndrome (ARDS) pathogenesis. Further research is needed to understand its actions for potential therapeutic benefits in lung injury.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictors of vaping relapse among young e-cigarette users: Machine learning-based survival analysis of a smartphone app-derived longitudinal data.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco·2026
Same author

Saccharomycetes and Malassezia fungi associate with early-life gut maturation and allergic disease risk in childhood.

Nature communications·2026
Same author

Do biologics improve health outcomes in children with severe asthma? A cohort study.

ERJ open research·2026
Same author

Early detection of chronic lung allograft dysfunction with spectral and intrabreath oscillometry.

JHLT open·2026
Same author

The Association of Maternal Dietary Patterns With Asthma and Wheeze Diagnosis in Canadian Children.

Nutrition bulletin·2026
Same author

Vaccination attitudes and intentions reported by Canadian children and their parents in the CHILD Cohort Study during the COVID-19 pandemic.

BMC public health·2026

Area of Science:

  • Pulmonary Medicine
  • Inflammation Research
  • Biochemistry

Background:

  • Acute respiratory distress syndrome (ARDS) is an inflammatory lung condition triggered by various insults.
  • Neutrophils and their products, like neutrophil elastase, are implicated in ARDS development.
  • Refractory hypoxemia and severe respiratory distress characterize ARDS.

Purpose of the Study:

  • To review the physiological actions of proteases, specifically neutrophil elastase.
  • To examine the evidence linking neutrophil elastase to ARDS.
  • To explore the potential of neutrophil elastase inhibitors as therapeutics for lung injury.

Main Methods:

  • Literature review of published articles and reviews.
  • English language publications from 1965 to 2002 were included.

Related Experiment Videos

  • Focus on physiological actions, ARDS involvement, and therapeutic potential.

    • Main Results:

    • Neutrophil elastase is a significant factor in the pathophysiology of ARDS.
    • Proteases, particularly elastase, have distinct physiological functions.
    • Evidence supports the involvement of neutrophil elastase in lung injury.

    Conclusions:

    • Neutrophil elastase is crucial in ARDS pathogenesis.
    • Further investigation is required to fully elucidate neutrophil elastase actions.
    • Understanding these actions is key to developing effective therapeutic strategies for ARDS.