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Updated: Aug 10, 2026

Murine Model of CD40-activation of B cells
Published on: March 5, 2010
Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia
C Campàs1, M Dalmau, B Montaner
1Department de Ciències Fisiològiques II, Unitat de Bioquímica, Facultat de Medicine, Universtitat de barcelona, Spain.
Abstract:
We have previously reported that prodigiosin (2-methyl-3-pentyl-6-methoxyprodigiosene) induces apoptosis in human hematopoietic cancer cell lines with no marked toxicity in nonmalignant cell lines. In this study, we demonstrate that prodigiosin induces apoptosis of B-cell chronic lymphocytic leukemia (B-CLL) cells (n=32 patients). The dose-response for the cytotoxic effect of prodigiosin was analyzed in cells from 12 patients showing an IC(50) of 116+/-25 nM. Prodigiosin induced apoptosis of B-CLL cells through caspase activation. We also analyzed the cytotoxic effect of prodigiosin in T cells from B-CLL samples and no differences were observed with respect to leukemia cells. This is the first report showing that prodigiosin induces apoptosis in human primary cancer cells.
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