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Updated: Aug 8, 2026

An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse
Published on: April 7, 2014
[Angiogenesis and lymphangiogenesis in the cornea. Pathogenesis, clinical implications and treatment options]
C Cursiefen1, B Seitz, M R Dana
1Augenklinik mit Poliklinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen. cursiefen@vision.eri.harvard.de
Background:
Whereas the normal cornea is devoid of blood and lymphatic vessels,both can invade the cornea secondary to a variety of corneal diseases and after surgery. This not only reduces visual acuity, but also renders such a cornea high-risk, if subsequent corneal transplantation is performed.
Methods:
A PUBMED-based literature search was carried out.
Results:
Current knowledge on pathogenesis, clinical implications and treatment modalities for corneal neovascularization is discussed.
Conclusions:
Novel anti-angiogenic and antilymphangiogenic therapeutic strategies should reduce blindness associated with corneal neovascularization and subsequent graft rejection.
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