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Related Experiment Videos

Schizophrenia in late life.

Larry E Tune1, Carl Salzman

  • 1Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. ltune@emory.edu

The Psychiatric Clinics of North America
|April 10, 2003
PubMed
Summary

Antipsychotics effectively manage agitation and psychosis in late-life dementia. Atypical antipsychotics show promise for schizophrenia core symptoms, but more research is needed on optimal dosing and patient subgroup responses.

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Area of Science:

  • Geriatric Psychiatry
  • Pharmacology
  • Clinical Neuroscience

Background:

  • Late-life psychosis, particularly in dementia, is often treated with antipsychotics.
  • Conventional and atypical antipsychotics are primary treatment options.

Purpose of the Study:

  • To review the efficacy and safety of antipsychotics in late-life psychosis.
  • To identify areas for future research in treating late-life schizophrenia and dementia-related psychosis.

Main Methods:

  • Literature review of studies on antipsychotic use in elderly patients with psychosis.
  • Analysis of evidence for efficacy in behavioral dyscontrol versus core schizophrenic symptoms.

Main Results:

  • Atypical antipsychotics demonstrate therapeutic efficacy with a better side-effect profile than conventional agents.
  • Evidence for treating core symptoms of late-life schizophrenia is emerging, necessitating further trials.
  • Low therapeutic doses and vigilant side-effect monitoring are crucial.

Conclusions:

  • Atypical antipsychotics are effective for late-life psychosis, especially in managing behavioral symptoms.
  • Future research should differentiate between schizophrenia and secondary psychoses, and consider early-onset vs. late-onset schizophrenia, and illness severity.

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