Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cyclooxygenase-2 expression and function in renal pathophysiology.

Radko Komers1, Murray Epstein

  • 1Division of Nephrology and Hypertension, Oregon Health Sciences University, Portland, Oregon, USA.

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
|April 10, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sparsentan Versus Irbesartan in Pediatric Patients With FSGS.

Kidney international reports·2026
Same author

Promoting clinical trials in pediatric IgA nephropathy through extrapolation: an artificial intelligence-enhanced literature review of the disease in pediatrics sponsored by the Kidney Health Initiative.

Pediatric nephrology (Berlin, Germany)·2026
Same author

Antiproteinuric Effect of Sparsentan in Patients with Genetic-Associated FSGS Enrolled in the DUPLEX Trial.

Clinical journal of the American Society of Nephrology : CJASN·2025
Same author

Association between Complete Proteinuria Remission and Kidney Function in the Phase 3 PROTECT Trial of Sparsentan in IgA Nephropathy.

Clinical journal of the American Society of Nephrology : CJASN·2025
Same author

Sparsentan in IgA nephropathy: a plain language summary of publication for the PROTECT study.

Therapeutic advances in rare disease·2025
Same author

Framework for precision medicine in focal segmental glomerulosclerosis: Translation of sparsentan-responsive genes in a rat model to kidney disease associated proteins in biofluids.

medRxiv : the preprint server for health sciences·2025
Same journal

Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats.

Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
Same journal

Hypertension and kidney alterations in rat offspring from low protein pregnancies.

Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
Same journal

Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension.

Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
Same journal

The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance.

Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
Same journal

Chronic antioxidant therapy fails to ameliorate hypertension: potential mechanisms behind.

Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
Same journal

Endothelial dysfunction in spontaneously hypertensive rats: focus on methodological aspects.

Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
See all related articles

Cyclooxygenase-2 (COX-2) plays a key role in various diseases, influencing prostaglandin production. Understanding its complex regulation is crucial for developing targeted COX-2 inhibitor therapies, avoiding harmful side effects.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Pathophysiology

Background:

  • Cyclooxygenase (COX) is the rate-limiting enzyme in prostaglandin biosynthesis.
  • Altered COX-2 activity and expression are implicated in various pathophysiological states.
  • COX-2's role extends beyond inflammation, including constitutive prostanoid production in the kidney.

Purpose of the Study:

  • To explore the multifaceted roles of COX-2 in health and disease.
  • To identify new therapeutic targets for COX-2-specific inhibitors.
  • To delineate situations where COX-2 inhibitors may be beneficial or detrimental.

Main Methods:

  • Review of experimental evidence on COX-2 activity and expression.
  • Analysis of pathophysiological states associated with altered COX-2 regulation.

Related Experiment Videos

  • Examination of COX-2's role in both inducible and constitutive prostanoid production.

    • Main Results:

    • COX-2 has a pathogenetic role in certain disease states.
    • The effects of altered COX-2 regulation are not always clear and can be beneficial.
    • COX-2 is involved in constitutive kidney function, not solely inflammatory induction.

    Conclusions:

    • Targeted COX-2 inhibition offers potential therapeutic avenues.
    • Careful consideration of COX-2's diverse roles is necessary to guide inhibitor use.
    • Avoiding COX-2 inhibitors in specific conditions is essential to prevent adverse outcomes.