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Canine transitional cell carcinoma.

Anthony J Mutsaers1, William R Widmer, Deborah W Knapp

  • 1Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN 47907-1248, USA.

Journal of Veterinary Internal Medicine
|April 10, 2003
PubMed
Summary
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Canine transitional cell carcinoma (TCC) of the urinary bladder is a common and challenging cancer. Research into risk factors, treatment, and its similarity to human bladder cancer may benefit both species.

Area of Science:

  • Veterinary Oncology
  • Comparative Pathology

Background:

  • Transitional cell carcinoma (TCC) is the most prevalent urinary tract malignancy in dogs.
  • Canine TCC presents diagnostic and therapeutic challenges, with potentially increasing prevalence.
  • Risk factors include breed, gender, and environmental exposures like insecticides.

Purpose of the Study:

  • To review the current understanding of canine transitional cell carcinoma (TCC).
  • To highlight challenges in diagnosis and treatment of TCC in dogs.
  • To emphasize the comparative relevance of canine TCC to human bladder cancer research.

Main Methods:

  • Literature review of epidemiological, clinical, and research studies on canine TCC.
  • Analysis of risk factors, diagnostic methods, and treatment modalities.

Related Experiment Videos

  • Comparison of canine TCC characteristics with human invasive urinary bladder cancer.

    • Main Results:

    • Canine TCC etiology is multifactorial, with identified breed, gender, and environmental risk factors.
    • Surgical removal is difficult, and chemotherapy response is often poor.
    • The tumor/node/metastasis (TNM) classification aids in identifying prognostic factors.
    • Urinary tract obstruction and metastasis are significant treatment challenges.

    Conclusions:

    • Canine TCC shares significant similarities with human invasive urinary bladder cancer.
    • Further research into TCC, including novel treatments like cyclooxygenase inhibitors, is warranted.
    • Advancements in understanding canine TCC hold potential benefits for both canine and human health.