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Synthesis and cytotoxic evaluation of novel thiazolocarbazoles
Christelle Lamazzi1, Hadjila Chabane, Valerie Thiery
1Institut de Chimie Organique et Analytique, UMR-CNRS 6005, Université d'Orléans, rue de Chartres, BP 6759, F-45067 Orleans cedex 2, France.
Journal of Enzyme Inhibition and Medicinal Chemistry
|April 10, 2003
Abstract:
Novel thiazolocarbazole derivatives 4 and 5 have been synthesized via the corresponding imino-1,2,3-dithiazoles 3. In vitro antitumor activity of these polyheterocyclic compounds was studied and the results show that 2-cyano derivatives exhibit a medium in vitro antiproliferative effect.