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Synthesis and antimalarial activity of some new 1,2-dioxolane derivatives
Jean-Jacques Helesbeux1, Damien Peyronnet, Mehdi Labaïed
1SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, 16 Bd Daviers, 49100 Angers, France.
Journal of Enzyme Inhibition and Medicinal Chemistry
|April 10, 2003
Abstract:
The synthesis of 1,2-dioxolane derivatives in two different acetophenone series, as simplified models of natural coumarins is described. 2-Acetyl-3-acetoxy-4-(3-hydroperoxy-3-methylbut-1-enyl)phenyl acetate and 2-acetyl-5-acetoxy4-(3-hydroperoxy-3-methylbut-1-enyl) phenyl acetate synthons are used as precursors to these structures. In vitro antimalarial activity of the 1,2-dioxolane derivatives has been investigated.