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Management of patients refractory to platelet transfusion
Ronald A Sacher1, Thomas S Kickler, Charles A Schiffer
1University of Cincinnati Medical Center, Hoxworth Blood Center, Cincinnati, Ohio, USA. Ronald.Sacher@uc.edu
Insights
This resource provides a practical guide for diagnosing and managing patients refractory to platelet transfusions. It offers a contemporary approach to this challenging clinical problem.
Area of Science:
- Transfusion Medicine
- Hematology
- Clinical Pathology
Background:
- Platelet transfusion refractoriness presents a significant clinical management challenge.
- Accurate diagnosis and appropriate component selection are crucial for effective treatment.
Framework:
- A task force convened by the College of American Pathologists developed this approach.
- The framework is based on a current literature review and expert consensus.
Implementation:
- Outlines current concepts in defining and diagnosing platelet transfusion refractoriness.
- Provides guidance on selecting optimal platelet components for refractory patients.
Implications:
- Aims to serve as a practical resource for clinicians.
- Enhances patient care by improving outcomes for those refractory to platelet transfusions.
Objective:
To present a current assessment and practical approach to the diagnosis and management of patients who are refractory to platelet transfusions.
Design:
A task force was convened by the College of American Pathologists under the auspices of the Transfusion Medicine Resource Committee for the purposes of outlining current concepts in the definition and diagnosis of this difficult clinical management problem and selection of the optimal platelet component for these patients.
Results:
This article represents a contemporary approach to the diagnosis and management of patients who are refractory to platelet transfusions. This document is based on a current literature review and dialog among members of the task force convened to address the subject.
Conclusions:
It is hoped that this document will represent a resource and practical approach to the issue of diagnosis and management of patients who are refractory to platelet transfusions.