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The combined contraceptive ring NuvaRing and spermicide co-medication
1Kendle Clinical Pharmacology Unit, Utrecht, The Netherlands.
Contraception
|April 10, 2003
Abstract:
The effects of nonoxynol-9 on etonogestrel and ethinylestradiol release and absorption from NuvaRing were studied in 12 subjects for two cycles: one control and one interaction cycle (nonoxynol-9 was administered on day 8). Nonoxynol-9 had no effect on release or absorption and, consequently, serum levels. Therefore, nonoxynol-9 did not compromise the contraceptive efficacy of NuvaRing.