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INI-1, a partner gene of ALL-1, is highly conserved in human acute leukemia

Koshi Mimori1, Hiroshi Inoue, Hideshi Ishii

  • 1Department of Surgery, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu 874-0838, Japan.

Oncology Reports
|April 10, 2003
PubMed

Recently, much interest have been focused on the role of INI-1, a partner gene of transfusion protein All-1 for leukemogenesis of acute leukemia cases. We found the presence of a mutation at codon 152 in INI-1 that resulted in a conservative amino acid change in cDNA and genomic DNA from an AML patient. We also found the known polymorphic nucleotide change at the third letter of codon 299 in exon 7 of INI-1 in 3 of 31 ALL cases and in 4 of 30 AML cases. In conclusion, INI-1, a partner gene for ALL-1, is considered to be highly conserved in acute leukemia cases.

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