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Related Experiment Videos

Platelet function in the racing thoroughbred: implication for exercise-induced pulmonary hemorrhage.

Douglas J. Weiss1, Carolyn B. McClay, Clark M. Smith

  • 1College of Pathobiology, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108.

Veterinary Clinical Pathology
|January 1, 1990
PubMed
Summary

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Horses with exercise-induced pulmonary hemorrhage show normal platelet function, suggesting a predisposition to thrombus formation and potential microvascular obstruction in equine athletes.

Area of Science:

  • Equine physiology
  • Hematology
  • Exercise-induced pulmonary hemorrhage

Background:

  • Exercise-induced pulmonary hemorrhage (EIPH) is a common condition in athletic horses.
  • Understanding platelet function is crucial for evaluating hemostasis and thrombosis risk in horses.

Purpose of the Study:

  • To investigate and compare platelet function in horses with and without EIPH.
  • To assess platelet aggregation, secretion, and adhesion capabilities in relation to EIPH.

Main Methods:

  • Evaluated platelet aggregation, secretion, and adhesion to rabbit aortic subendothelium.
  • Tested platelet responses to various agonists including ADP, thrombin, collagen, and arachidonic acid.
  • Compared function between horses diagnosed as bleeders (EIPH) and non-bleeders (controls).

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Main Results:

  • Platelet aggregation, secretion, and adhesion were similar between bleeder and non-bleeder horses.
  • Platelets aggregated effectively with common agonists but secretion required high thrombin concentrations.
  • Platelets adhered readily to subendothelium, forming large thrombi instead of monolayers.

Conclusions:

  • Normal platelet function in horses with EIPH suggests other factors contribute to bleeding.
  • The tendency for thrombus formation indicates a potential predisposition to microvascular obstruction in horses.